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Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1

This is a very important and possibly crucial biochemical mechanism, since reversible thiolation of proteins can modify their enzymatic activities (glycolytic enzymes, components of the respiratory chain, creatine kinase, carbonic anhydrase), ion and metabolite transport, gene transcription, signal transduction and cell death

PMID 16984231

Cyanocobalamin | Drugs - BNF - NICE

These parameters are illustrated schematically in Figure 32 where the volume of the beakers into which the drugs diffuse represents the volume of distribution, and the size of the outflow drain in Figures 32B and 32D represents the clearance

Sensations often associated with joint pain include feeling achy, sore, or stiff in the joint, and has also been described as providing a burning, throbbing, or even a sensation of grating